Maikel Peppelenbosch Prof., MD, PhD (ErasmusMC)
Since 2009, I am professor of Experimental Gastroenterology at Erasmus Medical Center, Rotterdam. I studied Medicine at the University of Utrecht, the Netherlands and trained in Medical Biology between 1985 and 1989. In 1994, I completed my thesis (cum laude) on the Action and Function of Receptor Protein Tyrosine Kinases -the role of arachidonic acid metabolites and tyrosine phosphatases. I was Postdoctoral associate from 1993-1995 with Prof. dr Johannes L. Bos, Physiological Chemistry, at Utrecht University, with Dr Anne Ridley, at the Ludwig Institute for Cancer Research in London and with prof. dr. Walter Fiers in Gent, Belgium. After a spell as research leader at the Laboratory for Experimental Internal Medicine at the AMC in Amsterdam and a professorship of Cell Biology at the University of Groningen I took on my current position in Rottedam.
In the second half of the nineties, however, I became fascinated by the biology of gastrointestinal tract, trying to understand how the tract maintains histostasis in the face of the unrelenting sequence of cell proliferation, differentiation and apoptosis which takes place in the intestine. In addition, I wished to explore the mechanisms that enable the mucosal immune system to tolerate billions of commensal bacteria but adequately attack pathogens if they present themselves in the intestine. I have endeavoured to apply the insights gained for designing improved diagnosis and therapy, especially with respect to IBD, GE cancer and Barrett’s oesophagus. My research therefore ranges from very fundamental to clear clinical applications and innovations, in developed and developing countries.